Protection Activity of 1,4-Naphthoquinones in Rotenone-Induced Models of Neurotoxicity.

The MTS cell viability test was used to screen a mini library of natural and synthetic 1,4-naphthoquinone derivatives (1,4-NQs) from marine sources. This screening identified two highly effective compounds, and , which showed potential in protecting Neuro-2a neuroblastoma cells from the toxic effects of rotenone in an in vitro model of neurotoxicity. The selected 1,4-NQs demonstrated the capability to reduce oxidative stress by decreasing the levels of reactive oxygen species (ROS) and nitric oxide (NO) in Neuro-2a neuroblastoma cells and RAW 264.

Holothurian triterpene glycoside cucumarioside A-2 induces macrophages activation and polarization in cancer immunotherapy.

Background: Despite intensive developments of adoptive T cell and NK cell therapies, the efficacy against solid tumors remains elusive. Our study demonstrates that macrophage-based cell therapy could be a potent therapeutic option against solid tumors.

Methods: To this end, we determine the effect of a natural triterpene glycoside, cucumarioside A-2 (CA-2), on the polarization of mouse macrophages into the M1 phenotype, and explore the antitumor activity of the polarized macrophage.

Study of the Effect of Selective Media with High Doses of Zinc on Regeneration Ability and Rutin Accumulation in Common Buckwheat In Vitro.

Biotechnological methods are widely used in modern common buckwheat ( Moench) studies, constitute an effective tool to create the best agronomic traits of the crop, and can also be used to breed forms, resistant to heavy metal ion toxicity, which is important in the environment of constantly growing anthropogenic pressure on ecosystems. The studied high concentrations of zinc salts (808-1313 mg L) in the nutrient medium in vitro had an inhibitory effect on buckwheat, which was manifested by a decrease in values of its morphological indicators. Ion stress had an adverse effect on 7-9% of plants from their total number, indicating high plasticity and resistance of to highly toxic doses of zinc.

Influence of the Metabolites of the Marine Algicolous Fungus Penicillium sp. on Seedling Root Growth of Agricultural Plants.

N-Methylpretrichodermamide B (I), pretrichodermamide C (H), quinolactacide (III) and 8-methoxy-3,5-dimethyl-3,4-dihydro-IH-isochromen-6-ol (IV), isolated from the marine fungus Penicillium sp., were examined for their ability to stimulate growth of seedling roots of buckwheat (Fagopyrum esculentum Moench), wheat (Triticum aestivum L.), soy {Glycine max (L.

Influence of Merosesquiterpenoids from Marine Sponges on Seedling Root Growth of Agricultural Plants.

The impact of the merosesquiterpenoids avarol (1), avarone (2), 18-methylaminoavarone (3), melemeleone A (4), isospongiaquinone (5), ilimaquinone (6), and smenoquinone (7), isolated from marine sponges of the Dictyoceratida order, was studied on the root growth of seedlings of buckwheat (Fagopyrumesculentum Moench), wheat (Triticumaestivum L.), soy (Glycine max (L.) Merr.