The Effect of Estrogen-Related Genetic Variants on the Development of Uterine Leiomyoma: Meta-analysis.

Uterine leiomyoma is the most common benign gynecological tumor in women of reproductive age. It has been diagnosed approximately in 5 to 69% of women and was symptomatic in 30% of them. The underlying pathobiology of uterine leiomyoma is not well understood yet, but it can be defined as an estrogen-dependent tumor.

[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)].

Objective: The analyze the neuro-ophthalmic outcomes in patients with pineal and suprasellar germinoma after complex treatment.

Material And Methods: There were 125 patients (88 males, 37 females) with primary CNS germinoma for the period 2008-2017. All patients were divided into 3 groups depending on the tumor localization: pineal area - 62 patients, suprasellar neoplasm - 38 patients, bifocal germinoma - 25 patients.

[Neuro-ophthalmological symptoms in patients with pineal and suprasellar germinoma].

Purpose: To analyze neuro-ophthalmology symptoms in patients with germinomas located in pineal and suprasellar regions.

Material And Methods: The study analyzed 133 patients with germinoma who were receiving treatment in Burdenko Neuro-surgical Institute from 2008 to 2017. Assessment of results was performed by neuro-ophthalmology examination, a computerized oculograph was used for the objectification of the severity of ocular-motor and pupillary disorders.

Association of Growth Factors Genes with Miscarriage.

Background: The study was aimed to investigate the association of V gene polymorphic variants - (rs699947) and - (rs2010963) and gene (rs1800471) and gene expression level with miscarriage in the first trimester.

Methods: 288 women with different courses of pregnancy and 61 chorionic tissue samples were involved in case-control study. Allele-specific polymerase chain reaction in real time was used for genotyping.

[Preoperative and postoperative ophthalmic symptoms in patients with space-occupying lesions of the midbrain and pineal region].

Unlabelled: The most common clinical manifestations of space-occupying lesions of the midbrain and pineal region are oculomotor and pupil disorders and ophthalmoscopic signs of intracranial hypertension.

Purpose: To identify patterns of neuro-ophthalmic symptoms before and after surgical treatment in patients with space-occupying lesions of the midbrain and pineal region.

Material And Methods: We analyzed neurological symptoms in 231 patients with space-occupying lesions of the midbrain and pineal region before and after surgical treatment.