[Parodontitis immunotropic therapy in patients with chronic viral and bacterial infections].

80 patients with chronic hepatitis and brucellosis were examined in order to determine the efficacy of cycloferon liniment in parodontitis treatment. It was established that the use of local cycloferon form in comprehensive treatment of parodontitis helped to speed up recovery process and to reduce the frequency of disease relapses. Normalization of lipid peroxidation and antioxidant defense processes indices with reduction of infectious loading of parodontal pockets fluid and normalization of local cytokines' status was noted.

Vesicular transport of extracellular acid phosphatases in yeast Saccharomyces cerevisiae.

A method for isolation of secretory vesicles from the yeast Saccharomyces cerevisiae based on the disintegration of protoplasts by osmotic shock followed by separation of the vesicles by centrifugation in a density gradient of Urografin was developed in this study. Two populations of the secretory vesicles that differ in density and shape were separated. Acid phosphatases (EC 3.

[Immunoenzyme test system for detecting antibodies to group-specific antigens of group A Streptococcus on the base of conjugated N-acetylglucosamine and its use in medical practice].

Enzyme immunoassay kit has been created for detecting antibodies to group A Streptococcus, based on N-acetylglucosamine. N-acetylglucosamine was selected as the group-specific determinant due to the structure of group A Streptococcus polysaccharide, in which this monosaccharide residue is lateral to the main polysaccharide chain and hence more available for antibodies. Water-soluble polyacrylamide is the carrier in this kit, for this carrier is stable and not liable to nonspecific reaction with proteins.

Antibodies against proteins of streptococcal hyaluronate synthase bind to human fibroblasts and are present in patients with rheumatic fever.

Antibodies directed against the streptococcal 42 kDa hyaluronate synthase and a 56 kDa auxiliary protein bound to the surface of intact human fibroblasts in vitro. Staining was most prominent during the detachment phase of mitosis. In eukaryotic plasma membranes a 52 kDa protein was recognized by the antiserum against the 56 kDa streptococcal protein.