IL-6 blockade in systemic juvenile idiopathic arthritis - achievement of inactive disease and remission (data from the German AID-registry).

Background: Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective drugs inhibiting their signaling are being developed. This study evaluates sJIA patients treated with the IL-6 inhibitor tocilizumab (TCZ) concerning clinical response rate, disease course and adverse effects in a real-life clinical setting.

An optical fiber infrasound sensor: a new lower limit on atmospheric pressure noise between 1 and 10 Hz.

A new distributed sensor for detecting pressure variations caused by distant sources has been developed. The instrument reduces noise due to air turbulence in the infrasound band by averaging pressure along a line by means of monitoring strain in a long tubular diaphragm with an optical fiber interferometer. Above 1 Hz, the optical fiber infrasound sensor (OFIS) is less noisy than sensors relying on mechanical filters.