Publications by authors named "E Hogg"
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise the proteomes of multiple hiPSC and hESC lines derived from independent donors and find that while they express a near-identical set of proteins, they show consistent quantitative differences in the abundance of a subset of proteins. hiPSCs have increased total protein content, while maintaining a comparable cell cycle profile to hESCs, with increased abundance of cytoplasmic and mitochondrial proteins required to sustain high growth rates, including nutrient transporters and metabolic proteins.
View Article and Find Full Text PDFMaternal Accommodation of Adolescent Body Dysmorphic Disorder: Clinical Correlates and Association with Treatment Outcomes.
Child Psychiatry Hum Dev
September 2024
Article Synopsis
- Family accommodation (FA) in adolescents with Body Dysmorphic Disorder (BDD) involves mothers engaging in behaviors like reassurance and assisting avoidance, which are common and linked to higher BDD symptom severity and maternal anxiety, depression, and stress levels.
- A study involving 131 adolescents with BDD found that most mothers practiced some form of accommodation, but this did not predict the treatment outcomes for the adolescents after cognitive behavioral therapy.
- The research suggests that while maternal accommodation is prevalent and associated with certain clinical factors, its impact on treatment response differs from what is observed in children with obsessive-compulsive disorder (OCD), indicating a need for more extensive longitudinal studies.
Article Synopsis
- Current estimates of genetic variants linked to Parkinson's disease (PD) show limitations and biases across different populations, complicating patient recruitment for clinical trials focused on genetic therapies.
- The Rostock Parkinson's disease (ROPAD) study analyzes data from 12,580 PD patients across 16 countries, revealing that 14.8% had a genetic test positive for PD-related variants, particularly in specific genes like GBA1 and LRRK2.
- Findings indicate higher positivity rates in patients with earlier onset (age ≤ 50) or a positive family history, emphasizing the need for more extensive genetic investigation to improve patient stratification for future clinical trials.
The generation of distinct cell fates during development depends on asymmetric cell division of progenitor cells. In the central and peripheral nervous system of progenitor cells respectively called neuroblasts or sensory organ precursors use PAR polarity during mitosis to control cell fate determination in their daughter cells. How polarity and the cell cycle are coupled, and how the cell cycle machinery regulates PAR protein function and cell fate determination is poorly understood.
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