Publications by authors named "E Hills"
Mendelian randomization assessing causal relationship between fibrinogen levels and ischemic stroke.
J Stroke Cerebrovasc Dis
December 2024
Article Synopsis
- High fibrinogen levels are linked to a higher risk of ischaemic stroke (IS), suggesting a potential causal relationship explored using Mendelian randomization (MR).
- A meta-analysis involving 24 studies and over 20,000 IS cases revealed that certain gene variants (like FGB rs1800790) are associated with increased fibrinogen levels, which in turn raise IS risk.
- The analysis showed that each 1g/L increase in fibrinogen correlates with more than double the risk of experiencing an ischaemic stroke.
Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task activation protocols, but with significant methodological heterogeneity between studies, hindering cross-study comparisons. Therefore, this review aimed to summarise and compare available methods for TCD-based healthy NVC assessments.
View Article and Find Full Text PDFBackground: The relationship between dynamic cerebral autoregulation (dCA) and functional outcome after acute ischemic stroke (AIS) is unclear. Previous studies are limited by small sample sizes and heterogeneity.
Methods: We performed a 1-stage individual patient data meta-analysis to investigate associations between dCA and functional outcome after AIS.
Using Hormone Data and Age to Pinpoint Cycle Day within the Menstrual Cycle.
Medicina (Kaunas)
July 2023
: Menstrual cycle tracking is essential for reproductive health and overall well-being. However, there is still an over-reliance on estimations that standard cycles are 28 days long, divided evenly between the follicular and luteal phases. Due to the variability of cycle length and cycle phase lengths, common methods of identifying where an individual is in their cycle are often inaccurate.
View Article and Find Full Text PDFHydroxyurea (HU), a drug for treating cancers of the blood and the management of sickle cell anemia, induces hypogonadism in males. However, the impact of HU on testicular architecture and function, as well as its effects on the resumption of male fertility following treatment withdrawal, remain poorly understood. We used adult male mice to determine whether HU-induced hypogonadism is reversible.
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