Publications by authors named "E Hazrati"
Background: Interleukin-18 (IL-18) is recognized for its pro-inflammatory properties and plays a central role in the progression of rheumatoid arthritis (RA). The specific single-nucleotide polymorphisms (SNPs), rs1946518 (-607C>A) and rs187238 (-137G), that are found in the IL-18 promoter region can potentially impact the expression of the IL-18 gene. This study aimed to investigate the correlation between these two polymorphisms and RA in the Iranian population.
View Article and Find Full Text PDFBackground: Glioblastoma multiforme (GBM) is one of the most invasive types of brain cancer. LncRNAs can be considered a new prognostic and diagnostic biomarker in GBM. This study comprehensively explored the interaction of lncRNAs with mRNAs in the TCGA database and proposed a novel promising biomarker with favorable diagnostic and prognostic values.
View Article and Find Full Text PDFPulmonary Hypertension and Right Ventricle: A Pathophysiological Insight.
Clin Med Insights Cardiol
September 2024
Background: Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by elevated pulmonary vascular pressure. Long-term PH, irrespective of its etiology, leads to increased right ventricular (RV) pressure, RV hypertrophy, and ultimately, RV failure.
Main Body: Research indicates that RV failure secondary to hypertrophy remains the primary cause of mortality in pulmonary arterial hypertension (PAH).
Article Synopsis
- * The kynurenine pathway is crucial for breaking down tryptophan and impacts neurotransmitter regulation, immune responses, and inflammation, making it relevant to various chronic pain conditions and MDD.
- * Research indicates that specific metabolites from this pathway can either protect or damage the nervous system, and targeting this pathway may lead to new, non-opioid pain management strategies.
Background: Intravenous lidocaine has shown promise as an effective analgesic in various clinical settings, but its utility for pain management in emergency departments, especially for bone fractures, remains relatively understudied.
Objective: This study compared intravenous lidocaine to pethidine for femoral bone fracture pain management.
Methods: This double-blind, randomized, controlled clinical trial was conducted in the emergency department of AJA University of Medical Sciences affiliated hospitals.