Publications by authors named "E Harigua-Souiai"
Computer-aided drug discovery (CADD) is nurtured by late advances in big data analytics and Artificial Intelligence (AI) towards enhanced drug discovery (DD) outcomes. In this context, reliable datasets are of utmost importance. We herein present CidalsDB a novel web server for AI-assisted DD against infectious pathogens, namely Leishmania parasites and Coronaviruses.
View Article and Find Full Text PDFApproved drugs successfully repurposed against based on machine learning predictions.
Front Cell Infect Microbiol
October 2024
Article Synopsis
- Drug repurposing is a cost-effective method to find new treatments for Neglected Tropical Diseases like Leishmaniasis, utilizing existing FDA-approved drugs.
- In a recent study, five out of ten predicted drug candidates showed effective anti-leishmanial properties, with Acebutolol, Prilocaine, and Phenylephrine being newly identified as potential treatments.
- Two compounds, Dibucaine and Domperidone, demonstrated particularly low inhibitory concentrations (IC values), indicating strong antileishmanial activity without significant toxicity to host cells.
Bluetongue virus (BTV) is an arbovirus considered as a major threat for the global livestock economy. Since 1999, Tunisia has experienced several incursions of BTV, during which numerous cases of infection and mortality have been reported. However, the geographical origin and epidemiological characteristics of these incursions remained unclear.
View Article and Find Full Text PDFKey Clinical Message: We report the first case of pathologic complete response (pCR) to neoadjuvant imatinib in a gastric stromal tumor harboring mutations in both exons 11 and 9. The significance of this co-occurrence is unknown and might increase the responsiveness of gastrointestinal stromal tumors (GISTs) to imatinib.
Abstract: pCR of GIST to neoadjuvant imatinib is rare.
Previous investigations of the eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure of LieIF4A inhibitors on the RNA-dependent ATPase activity of LieIF4A and its mammalian ortholog (eIF4AI). We compared their biochemical effects on RNA-dependent ATPase activities of both proteins and investigated if rocaglamide, a known inhibitor of eIF4A, could affect LieIF4A as well.
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