Structure-guided discovery of anti-CRISPR and anti-phage defense proteins.

Bacteria use a variety of defense systems to protect themselves from phage infection. In turn, phages have evolved diverse counter-defense measures to overcome host defenses. Here, we use protein structural similarity and gene co-occurrence analyses to screen >66 million viral protein sequences and >330,000 metagenome-assembled genomes for the identification of anti-phage and counter-defense systems.

Cheaper microscope may bring protein mapping to the masses.

Team solves first protein structures with lower cost device.

Geological hydrogen wins first major funding.

$20 million grant program by ARPA-E aims to jump-start work on climate-friendly fuel.