Knowledge, attitude and practice towards pharmacovigilance and reporting of adverse drug reactions among health care professionals in Albania: A cross-sectional study.

In both developed and developing nations, the rising prevalence of adverse drug reactions (ADRs) and underreporting of ADRs in pharmacovigilance centers have become major problems. The goal of this study was to access the overall knowledge, attitude and practices toward pharmacovigilance and ADRs reporting among Albanian healthcare professionals. A cross-sectional questionnaire-based study was conducted from December 2021 to February 2022 including physicians, community pharmacists and nurses in Tirana, Albania.

Emerging compounds and therapeutic strategies to treat infections from : an overhaul of the last 5-years patents.

Introduction: Human African Trypanosomiasis is a neglected disease caused by infection from parasites belonging to the species. Only six drugs are currently available and employed depending on the stage of the infection: pentamidine, suramin, melarsoprol, eflornithine, nifurtimox, and fexinidazole. Joint research projects were launched in an attempt to find new therapeutic options for this severe and often lethal disease.

Nanoencapsulation of essential oil into liposomes with anticancer potential.

L. essential oil possesses a wide spectrum of biological activities. Nanoencapsulation of essential oil into liposomes seems to be a promising strategy to maintain and improve these biological properties.

Synthesis and Biological Evaluation of Carvacrol-Based Derivatives as Dual Inhibitors of Strains and AGS Cell Proliferation.

This study reports on the synthesis, structural assessment, microbiological screening against several strains of and antiproliferative activity against human gastric adenocarcinoma (AGS) cells of a large series of carvacrol-based compounds. Structural analyses consisted of elemental analysis, H/C/F NMR spectra and crystallographic studies. The structure-activity relationships evidenced that among ether derivatives the substitution with specific electron-withdrawing groups (CF and NO) especially in the para position of the benzyl ring led to an improvement of the antimicrobial activity, whereas electron-donating groups on the benzyl ring and ethereal alkyl chains were not tolerated with respect to the parent compound (MIC/MBC = 64/64 µg/mL).