Publications by authors named "E H von Hofe"
While the majority of thyroid cancer patients are easily treatable, those with anaplastic or poorly differentiated recurrent thyroid carcinomas have a very poor prognosis with a median survival of less than a year. Previously, we have shown a significant correlation between ICAM-1 overexpression and malignancy in thyroid cancer, and have pioneered the use of ICAM-1 targeted CAR T cells as a novel treatment modality. For clinical translation of this novel modality, we designed CAR T cells possessing micromolar rather than nanomolar affinity to ICAM-1 to avoid cytotoxicity in normal cells with basal levels of ICAM-1 expression.
View Article and Find Full Text PDFArticle Synopsis
- The Ii-Key fragment enhances the binding of MHC class II epitopes, showing potential for generating stronger immune responses using hybrid peptides in mice.
- These Ii-Key/HER-2/neu776-790 hybrid peptides increased the proliferation and IFN-gamma production of CD4+ T cells compared to the native peptide, demonstrating better stability and effectiveness in activating T cells.
- Furthermore, the combination of CD4+ and CD8+ T cells from hybrid peptide immunized mice provided significant antitumor immunity, leading to tumor regression in SCID mice with human melanoma grafts.