Publications by authors named "E H Zuniga"
Article Synopsis
- Plasmacytoid Dendritic cells (pDCs) are essential for producing interferons, which help the body fight viral infections, but their development is hindered during such infections.
- In a study using mice infected with lymphocytic choriomeningitis virus (LCMV), researchers found that DC progenitors shifted from developing into pDCs towards conventional dendritic cells (cDCs), leading to decreased pDC numbers.
- The study identified that glucocorticoids (GCs) play a significant role in suppressing pDC generation, linking the impaired development of pDCs after viral infections to hormonal responses in the body.
Tissue-resident memory T (T) cells adapt to diverse environments, providing local long-term protection. In this issue of Immunity, Obers et al. and Raynor et al.
View Article and Find Full Text PDFThe objective of this work was to ascertain the nutritive value of six concentrate feedstuffs commonly used in guinea pig feed manufacturing through the substitution method. Six test diets were obtained by replacing the corresponding basal mixture with 40% corn, 50% barley, 45% wheat bran, 35% soybean meal, 30% pigeon pea, or 30% Leucaena leaf meal. Sixty-three guinea pigs were randomly assigned to one of the nine experimental diets (three basal diets and six test diets, with seven animals per diet).
View Article and Find Full Text PDFThe Chilean consensus on the use of SGLT-2 inhibitors (iSGLT-2) in clinical practice, jointly developed by the societies of Cardiology, Diabetes, Family Medicine, and Nephrology, strongly recommends the use of these drugs in people with heart failure with reduced ejection fraction, type 2 diabetes mellitus for prevention of cardiovascular events, and chronic kidney disease. In heart failure with preserved or mildly reduced ejection fraction, and chronic kidney disease without diabetes, the consensus suggests the use of iSGLT-2. The importance of combining iSGLT-2 with ACE inhibitors or ARBs in chronic kidney disease is highlighted, and their use is recommended to replace sulfonylureas as a second-line treatment for glycemic control in type 2 diabetes.
View Article and Find Full Text PDFArticle Synopsis
- Chronic infections can lead to CD8 T cell exhaustion, which diminishes their ability to fight infections, but the role of metabolites in this process is not fully understood.
- Researchers used a virus model in mice to analyze metabolite changes during acute and chronic infections, finding notable differences in nutrients, especially during the early phase of chronic infection.
- The study highlights the importance of long-chain fatty acids in affecting T cell function and metabolism, providing insights into potential strategies for improving immune responses during prolonged infections.