Omics-driven onboarding of the carotenoid producing red yeast Xanthophyllomyces dendrorhous CBS 6938.

Transcriptomics is a powerful approach for functional genomics and systems biology, yet it can also be used for genetic part discovery. Here, we derive constitutive and light-regulated promoters directly from transcriptomics data of the basidiomycete red yeast Xanthophyllomyces dendrorhous CBS 6938 (anamorph Phaffia rhodozyma) and use these promoters with other genetic elements to create a modular synthetic biology parts collection for this organism. X.

Implementing a pain psychology screening process in primary care.

Background: Integrating pain psychology in primary care has the potential to improve symptom burden; however, identifying those who may benefit is a challenge. The purpose of this study was to gather feedback from a multidisciplinary team to optimize digital screening and referral for psychological treatment of chronic pain distress within primary care.

Method: Team members in a primary care clinic were introduced to the proposed screening process and offered the opportunity to complete a feedback survey.

Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines.

HRD is common in cancer and can be exploited therapeutically, as it sensitizes cells to DNA-damaging agents. Here, we scored more than 1,300 cancer cell lines for HRD using two different bioinformatic approaches, thereby enabling large-scale analyses that provide insights into the etiology and features of HRD.

Utilizing primary care to engage underserved patients in a psychological intervention for chronic pain.

Background: Although psychological interventions can be used to improve chronic pain management, underserved individuals (i.e., racially minoritized and socioeconomically disadvantaged) may be less likely to engage in such services.