Clinical outcomes of uninterrupted embryo culture with or without time-lapse-based embryo selection versus interrupted standard culture (SelecTIMO): a three-armed, multicentre, double-blind, randomised controlled trial.

Background: Time-lapse monitoring is increasingly used in fertility laboratories to culture and select embryos for transfer. This method is offered to couples with the promise of improving pregnancy chances, even though there is currently insufficient evidence for superior clinical results. We aimed to evaluate whether a potential improvement by time-lapse monitoring is caused by the time-lapse-based embryo selection method itself or the uninterrupted culture environment that is part of the system.

A short versus a long time interval between semen collection and intrauterine insemination: a randomized controlled clinical trial.

Study Question: Does a short interval (i.e. ≤90 min), compared to a long interval (i.

A cohort study on factors impairing semen quality in transgender women.

Background: Transgender women (people assigned male genders at birth with female gender identities) can choose to cryopreserve semen before their medical transition, to retain the possibility to parent genetically related offspring later in life. Our previous retrospective study showed that semen quality in transgender women was decreased compared with the general population. The etiology of this impaired semen quality remains largely unknown.

Effect of parental and ART treatment characteristics on perinatal outcomes.

Study Question: Do parental characteristics and treatment with ART affect perinatal outcomes in singleton pregnancies?

Summary Answer: Both parental and ART treatment characteristics affect perinatal outcomes in singleton pregnancies.

What Is Known Already: Previous studies have shown that singleton pregnancies resulting from ART are at risk of preterm birth. ART children are lighter at birth after correction for duration of gestation and at increased risk of congenital abnormalities compared to naturally conceived children.

Impaired semen quality in trans women: prevalence and determinants.

Study Question: What is the semen quality in trans women at time of fertility preservation, prior to the start of gender-affirming hormone treatment?

Summary Answer: Before the start of gender-affirming hormone treatment, semen quality in trans women was already strongly decreased compared to the general population.

What Is Known Already: Hormone treatment for -trans women (birth-assigned males, female gender identity) consists of anti-androgens combined with estrogens in order to achieve feminization and it is accompanied by a loss of reproductive capability. Trans women can opt for semen cryopreservation prior to their medical transition to retain the possibility to parent genetically related offspring.