Publications by authors named "E H Jho"

Article Synopsis
  • Advanced pancreatic ductal adenocarcinomas (PDACs) have a poor response to all existing therapies, making effective treatment a significant challenge for patients with late-stage disease.
  • Researchers discovered a new chemo-induced signaling network that contributes to chemoresistance in PDAC, highlighting Yap1 in cancer cells and Cox2 in stromal fibroblasts as critical components.
  • Co-targeting both Yap1 and Cox2 markedly increased the effectiveness of Gemcitabine treatment in mice, and patient data suggested that combining statins and Cox2 inhibitors with Gemcitabine could enhance survival rates for PDAC patients.
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This study investigates the effects of food waste biochar (FWB) on the biological properties of soil, including the microbial community structure, enzyme activities, lettuce growth, and earthworm ecotoxicity. This holistic assessment of various soil organisms was used to assess the potential of FWB as a soil amendment strategy. Pot experiments were carried out over a 28-d period using various FWB concentrations in soil (0-3% w/w).

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Plastic pollution poses a significant threat to environmental and human health, with microplastics widely distributed across various ecosystems. Although current ecotoxicological studies have primarily focused on the inherent toxicity of plastics in natural environments, the role of chemical additives leaching from plastics into the environment remains underexplored despite their significant contribution to the overall toxic potential of plastics. Existing systematic studies on plastic leachates have often examined isolated additive compounds, neglecting the ecotoxicological effects of multiple compounds present in plastic leachates.

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Cells sense and respond to various mechanical forces from the extracellular matrix primarily by modulating the actin cytoskeleton. Mechanical forces can be translated into biochemical signals in a process called mechanotransduction. Yes-associated protein (YAP) is an effector of Hippo signaling and a mediator of mechanotransduction, but how mechanical forces regulate Hippo signaling is still an open question.

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Plastics are widely used worldwide due to their convenience. However, microplastics (MPs) accumulation poses a serious threat to ecosystem health. Therefore, understanding the effects of MPs on living organisms within their native ecosystem is crucial.

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