Publications by authors named "E H DeCarlo"
Background: Vitamin A is vital to retinal rod function and epithelial cell differentiation. Although uncommon in the developed world, vitamin A deficiency (VAD) secondary to poor diets or gastrointestinal disease has been reported and can lead to xerophthalmia, which is characterized by night blindness and a spectrum of ocular surface changes. Patients with autism spectrum disorder have been shown to have restrictive diets secondary to sensory issues leading to rejection of foods except for those of certain color or texture.
View Article and Find Full Text PDFBubaline alphaherpesvirus 1 (BuHV-1) is a pathogen of water buffaloes responsible for economic loss worldwide. MicroRNAs (miRNAs) regulate gene expression produced by alphaherpesviruses and hosts. This study aimed at (a) unravelling the ability of BuHV-1 to produce miRNAs, including hv1-miR-B6, hv1-miR-B8, hv1-miR-B9; (b) measuring the host immune-related miRNAs associated to herpesvirus infection, including miR-210-3p, miR-490-3p, miR-17-5p, miR-148a-3p, miR-338-3p, miR-370-3p, by RT-qPCR; (c) identifying candidate markers of infection by receiver-operating characteristic (ROC) curves; (d) exploiting the biological functions by pathway enrichment analyses.
View Article and Find Full Text PDFArticle Synopsis
- Telomeres, which are repetitive sequences at chromosome ends, shorten with cell division and are linked to aging and stress levels.
- This study compared telomere length in leukocytes from different age groups of water buffaloes, finding a significant decrease in older cows (3rd lactation) compared to younger ones.
- The research also tested if telomere length could be measured from nasal and vaginal swabs as a non-invasive method, but found weak correlation with blood samples and deemed swabbing unsuitable for accurate telomere studies.
Article Synopsis
- Brucellosis, caused by Brucella bacteria, is an infectious disease affecting animals, particularly ruminants like water buffaloes, and can lead to economic losses in animal production.
- The study aimed to identify specific microRNA (miRNA) profiles in the blood and vaginal fluids of water buffaloes infected with Brucella, using advanced sequencing and validation methods.
- Results indicated that 20 miRNAs were affected by the infection, showing promise as potential biomarkers for diagnosing Brucella infection and advancing our understanding of immune responses related to the disease.