Publications by authors named "E H Bos"
Background: Patients with glioma often report language complaints with devastating effect on daily life. Analysing spontaneous speech can help to understand underlying language problems. Spontaneous speech monitoring is also of importance during awake brain surgery: it can guide tumour resection and contributes to maintaining language function.
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- The study aimed to create a new onco-functional outcome (OFO) classification for glioblastoma patients, combining the goals of complete tumor resection and avoiding functional loss into four categories.
- Analyzing data from 858 patients over ten years, they found that the OFO classification significantly influenced overall survival (OS) and progression-free survival (PFS) rates, especially in certain tumor types.
- The results showed that achieving the best outcome (OFO1) was linked to improved survival rates and higher likelihood of receiving additional therapy, particularly with awake craniotomy procedures being more effective in avoiding deficits.
Kinesin and dynein-dynactin motors move endosomes and other vesicles bidirectionally along microtubules, a process mainly studied under in vitro conditions. Here, we provide a physiological bidirectional transport model following color-coded, endogenously tagged transport-related proteins as they move through a crowded cellular environment. Late endosomes (LEs) surf bidirectionally on Protrudin-enriched endoplasmic reticulum (ER) membrane contact sites, while hopping and gliding along microtubules and bypassing cellular obstacles, such as mitochondria.
View Article and Find Full Text PDFPurpose: Meningiomas classified as grade 2-3 according to the World Health Organisation (WHO) require combined surgery and in most cases radiotherapy (RT). Their initial management was evaluated using the Dutch Brain Tumour Registry.
Methods: The study included 393 patients aged ≥ 18 years with newly diagnosed meningioma WHO grade 2-3 between 2016 and 2021.
Peptide receptor radionuclide therapy (PRRT) using Lu-DOTA-TATE has recently been evaluated for the treatment of meningioma patients. However, current knowledge of the underlying radiation biology is limited, in part due to the lack of appropriate in vitro models. Here, we demonstrate proof-of-concept of a meningioma patient-derived 3D culture model to assess the short-term response to radiation therapies such as PRRT and external beam radiotherapy (EBRT).
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