Publications by authors named "E Gulbins"
Sphingolipids play a major role in the regulation of hepatocellular apoptosis and proliferation. We have previously identified sphingolipid metabolites as biomarkers of chronic liver disease and hepatocellular carcinoma. Human hepatocellular carcinoma cell lines were transfected with a plasmid vector encoding for acid sphingomyelinase.
View Article and Find Full Text PDFSphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally involved in signaling pathways controlling cell proliferation, differentiation, and death. The brain exhibits a particularly high concentration of sphingolipids and dysregulation of the sphingolipid metabolism due to ischemic injury is implicated in consecutive pathological events.
View Article and Find Full Text PDFArticle Synopsis
- Acid sphingomyelinase (ASM) inhibitors, like amitriptyline, aid in recovering from post-stroke depression and enhance neurological recovery through neurorestorative effects in stroke models.
- The study revealed that amitriptyline boosts the formation of mitochondrial reactive oxygen species (ROS) in both human endothelial cells and mice models, which plays a key role in its ability to promote angiogenesis.
- Furthermore, amitriptyline triggers a metabolic reprogramming in endothelial cells that reduces harmful stress while encouraging protective responses, with the antioxidant heme oxygenase-1 being crucial for mediating its angiogenic effects.