Publications by authors named "E Guedj"
Purpose: Neurological symptoms often prominent in post-acute sequelae of COVID-19 (PASC) necessitate deeper understanding. Our objective was to investigate brain metabolism in PASC and examine correlations with neurological symptoms during both the acute and chronic stages.
Methods: Eighty-seven adults experiencing PASC with neurocognitive symptoms were recruited in the PERSICOR prospective study and examined using brain [18F]FDG PET/CT.
Article Synopsis
- Biomarkers in psychiatry are essential for better diagnosis and management, and radionuclide imaging (PET and SPECT) shows potential for practical use, particularly in schizophrenia-spectrum disorders.
- A systematic review evaluated 56 longitudinal studies involving 1,329 patients, focusing on the impact of PET and SPECT imaging on diagnosis and treatment personalization.
- Key findings indicated that PET and SPECT can predict treatment responses and optimize dosages of antipsychotic medications, highlighting the need for more clinical trials to confirm these benefits.
This review examines the role of metabolic connectivity based on fluorodeoxyglucose-PET in understanding brain network organization across neurologic disorders, with a focus on neurodegenerative diseases. The article explores key methodologies for metabolic connectivity study and highlights altered connectivity patterns in Alzheimer's, Parkinson's, frontotemporal dementia, and other conditions. It also discusses emerging applications, including single-subject analyses and brain-organ interactions.
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- The COVID-19 pandemic has introduced long COVID, a severe and lingering post-illness condition affecting many individuals, leading to various health problems.
- The review examines the neurological and psychiatric effects of COVID-19, highlighting issues like astrocyte dysfunction and glutamate regulation that may lead to significant brain injury.
- It emphasizes the importance of advanced imaging techniques in diagnosing and managing long COVID, suggesting improvements in treatment strategies.
Introduction: Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. This cognitive impairment is associated with an increased permeability of blood-brain barrier (BBB) in rodents with CKD, linked to activation of aryl hydrocarbon receptor (AhR) by indoxyl sulphate (IS). The objective of the BREIN study was to confirm the increased BBB permeability in humans with CKD.
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