Publications by authors named "E Grogan"
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View Article and Find Full Text PDFBackground: Measurement of tumor markers from peripheral venous blood is an emerging tool to assist in the early diagnosis of lung cancer. Samples from the pulmonary artery and pulmonary artery wedge position (trans-pulmonary samples) are accessible via right-heart catheterization and, by virtue of their proximity to lung tumors, may increase diagnostic yield.
Case Presentation: We report a case of a 64 year-old woman from whom trans-pulmonary samples were obtained and who was diagnosed 16 months later with recurrent metastatic small cell lung cancer.
Background: Radiomics has shown promise in improving malignancy risk stratification of indeterminate pulmonary nodules (IPNs) with many platforms available, but with no head-to-head comparisons. This study aimed to evaluate transportability of radiomic models across platforms by comparing performances of a commercial radiomic feature extractor (HealthMyne) with an open-source extractor (PyRadiomics) on diagnosis of lung cancer in IPNs.
Methods: A commercial radiomic feature extractor was used to segment IPNs from computed tomography (CT) scans, and a previously validated radiomic model based on commercial features was used as baseline (ComRad).
Article Synopsis
- Pulmonary nodules can be challenging to assess, leading to delays in diagnosing cancer and unnecessary tests for non-cancerous conditions.
- This study evaluated the effectiveness of prediction models for assessing the likelihood of malignancy in nodules referred for biopsy, specifically using a cohort of 322 cases.
- The results indicated that commonly used models (Brock, Mayo Clinic, and VA) had limited accuracy, while the Herder model showed better performance when PET-CT scans were included, suggesting a need for improved diagnostic tools in this area.