Publications by authors named "E Gringeri"
To fully harness mesenchymal-stromal-cells (MSCs)' benefits during Normothermic Machine Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor and investigated its bio-molecular effects and clinical feasibility using rat and porcine models. The study involved three work packages: 1) Development (n = 5): MSC-bioreactors were subjected to 4 h-liverless perfusion; 2) Rat model (n = 10): livers were perfused for 4 h on the MSC-bioreactor-circuit or with the standard platform; 3) Porcine model (n = 6): livers were perfused using a clinical device integrated with a MSC-bioreactor or in its standard setup. MSCs showed intact stem-core properties after liverless-NMP.
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- This study looked at how different hospitals approach treating liver cancer, especially regarding liver transplants.
- They surveyed 75 hospital directors to see if those with liver transplant programs treat patients differently compared to those without.
- The results showed that hospitals with transplant programs were more likely to recommend transplants for certain types of liver cancer and other liver diseases than those without, showing a need for better communication between the two types of centers.
Article Synopsis
- * In a study of 149 patients aged 60 and older who underwent liver resection between 2014 and 2018, 24.8% were found to be sarcopenic, which significantly impacted their mortality and overall survival rates post-surgery.
- * The findings suggest that sarcopenic patients face poorer outcomes, especially if they experience complications and fail to achieve 'Textbook Outcome' (TO), which correlates with better 5-year survival rates compared to non-s