Publications by authors named "E Grasso"
Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm
November 2024
Background And Objectives: Recent studies suggest that the choroid plexus (CP) may function as a site of access of inflammatory cells into the CNS in multiple sclerosis (MS). Pediatric-onset MS (POMS) is characterized by a high inflammatory burden, as evidenced by a high relapse rate and volume of T2 lesions, making patients with POMS an informative population to evaluate choroid plexus volume (CPV). The objectives of the study were (1) to evaluate CPV at symptom onset in participants with POMS compared with healthy controls (HCs); (2) to evaluate changes in CPV in the first year of disease in participants with POMS; and (3) to evaluate associations between CPV, brain volumes, relapse activity, and disability in participants with POMS.
View Article and Find Full Text PDFBackground: Placental macrophages, Hofbauer cells (HBC) are the only fetal immune cell population within the stroma of healthy placenta along pregnancy. They are central players in maintaining immune tolerance during pregnancy. Immunometabolism emerged a few years ago as a new field that integrates cellular metabolism with immune responses, however, the immunometabolism of HBC has not been explored yet.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores the connection between Ollier disease (OD), acute myeloid leukemia (AML), and brain glioma (BG), which are distinct types of tumors but can occur in the same patient, and aims to find shared molecular pathways for potential treatment.
- - A systematic literature review was conducted, revealing that thirty-three patients with both OD and BG were identified in previous studies, and only one documented case linked OD with AML—our case included all three diseases.
- - The IDH R132H mutation was identified as a common genetic alteration in all three types of tumors, suggesting that targeted therapies using IDH1 inhibitors could provide new treatment options, although further research with larger groups is needed to validate these findings.
Impact of appropriateness in clinical practice: data from a single-centre nuclear cardiology laboratory.
Eur Heart J Imaging Methods Pract
September 2023
Aims: To verify the level of appropriateness of referral to our nuclear cardiology laboratory for stress myocardial perfusion imaging (MPI) and explore the correlation between test appropriateness patterns and ischaemia.
Methods And Results: In 1870 consecutive patients (mean age 73 ± 12 years; 33% female) undergoing MPI, the level of imaging test appropriateness was evaluated according to the 2023 Appropriate Use Criteria (AUC) and the current European Society of Cardiology (ESC) guidelines for the management of chronic coronary syndromes. The evidence of moderate-to-severe ischaemia (i.
Problem: The decidualization process conditions monocytes to the immunosuppressive and tolerogenic dendritic cell (DC)-10 profile, a DC subset with high IL-10 production. Since the implantation process implies an embryo-endometrium-immune crosstalk, here we focused on the ability of embryonic soluble factors to modify decidual DC conditioning accordingly with its quality.
Method Of Study: Human endometrial stromal cell line (HESC) decidualized with medroxyprogesterone and dibutyryl-cAMP (Dec) was stimulated with human embryo-conditioned media (ECM), classified as normal (ND) or impaired developed (ID) for 48 h (n = 18/group).