Publications by authors named "E Grandi"
Article Synopsis
- * Atrial fibrillation (AF), a common heart arrhythmia, shows significant variations between sexes in terms of its onset, frequency, presentation, and outcomes, but the foundational differences in heart function prior to AF development remain unclear.
- * This review emphasizes the importance of understanding these sex differences in atrial physiology and AF, along with the need for developing targeted treatments based on sex-specific characteristics.
Background: Increased vascular Ca1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling.
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- This study investigates sex-based differences in atrial fibrillation (AF) by examining calcium handling and arrhythmogenic events in male and female heart cells.
- The research finds that female atrial cardiomyocytes show more frequent calcium sparks and are more prone to spontaneous calcium releases compared to males, shedding light on the mechanisms behind these differences.
- Potential interventions, such as restoring t-tubules and inhibiting certain calcium handling proteins, may help reduce arrhythmogenic events, with combination therapies showing increased effectiveness, particularly in females.
Idiopathic ventricular fibrillation (IVF) is an unrefined diagnosis representing a heterogeneous patient group without a structural or genetic definition. IVF treatment is not mechanistic-based due to the lack of experimental patient-models. We sought to create a methodology to assess cellular arrhythmia mechanisms for IVF as a proof-of-concept study.
View Article and Find Full Text PDFAlthough whole grains have well-recognized protective effects against the development of cardiometabolic diseases, whole grain foods are poorly consumed by the general population. The aim of our study was to establish, at a population level, the vascular impact of a low intake of whole grain foods. From the initial cohort of the Brisighella Heart Study, we identified a population sample of 1503 individuals-including 720 men (47.
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