The impact of intensivists' base specialty of training on care process and outcomes of critically ill trauma patients.

Background: The care of the critically ill trauma patients is provided by intensivists with various base specialties of training. The purpose of this study was to investigate the impact of intensivists' base specialty of training on the disparity of care process and patient outcome.

Methods: We performed a retrospective review of an institutional trauma registry at an academic level 1 trauma center.

Self-Compassion and Well-being among Older Adults.

Two studies assessed the role of self-compassion as a moderator of the relationship between physical health and subjective well-being in the elderly. In Study 1, 132 participants, ranging in age from 67-90 years, completed a questionnaire that assessed their perceptions of their physical health, self-compassion, and subjective well-being. Participants who were in good physical health had high subjective well-being regardless of their level of self-compassion.

A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene.

Hypoxia is a strong stimulus for the transcription of a set of genes, including erythropoietin and vascular endothelial growth factor. Here we report on the cloning, functional significance, and expression of a complementary DNA (cDNA) that is involved in hypoxia-mediated expression of these 2 genes. The full-length cDNA encodes a predicted protein of 806 amino acids that contains a leucine zipper motif.

The role of tyrosine 15 in erythropoietin action.

The results of iodination inactivation of erythropoietin suggest that tyrosine 15 is required for biological activity. This was confirmed by site-directed mutagenesis. Substitution of tyrosine by alanine or isoleucine resulted in mutants with no biological activity, whereas substitution by phenylalanine yielded an active mutein.