Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons.

Despite advances in understanding molecular and cellular changes in the aging nervous system, the upstream drivers of these changes remain poorly defined. Here, we investigate the roles of non-neural tissues in neuronal aging, using the cutaneous PVD polymodal sensory neuron in Caenorhabditis elegans as a model. We demonstrate that during normal aging, PVD neurons progressively develop excessive dendritic branching, functionally correlated with age-related proprioceptive deficits.

ST-GMLP: A concise spatial-temporal framework based on gated multi-layer perceptron for traffic flow forecasting.

The field of traffic forecasting has been the subject of considerable attention as a critical component in alleviating traffic congestion and improving urban services. Given the regular patterns of human activities, it is evident that traffic flow is inherently periodic. However, most of existing studies restrict themselves to recent historical observations and typically yield structurally and computationally complex models, which greatly limits the forecasting accuracy and hinders the application of models in realistic situations.

Intuition in Occupational Therapists' Clinical Reasoning: A Scoping Review.

This scoping review aimed to map the various facets of intuition in occupational therapy (OT), from its definitions, theoretical frameworks, epistemological paradigms to practical applications, highlighting its role in decision-making. Following the Joanna Briggs Institute methodology, a systematic search of five databases from 1990 to August 2023 identified 337 records related to OT and intuition. After removing duplicates and applying eligibility criteria, 22 studies were included.

Severe corneal manifestations of graft-versus-host disease: experience of a tertiary referral center.

Purpose: Graft-versus-host disease (GVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). GVHD may affect several organs, including ocular manifestations, ranging from dry eye syndrome to sight-threatening corneal ulceration or perforation. Limited information is available about characteristics and treatments of ocular GVHD and its relation to general prognosis.