A prospective random study of a single agent versus combination antibiotics as therapy in penetrating injuries of the abdomen.

One hundred patients undergoing operation for penetrating and potentially contaminated wounds of the abdomen were given cefamandole or a combination of cephalothin-tobramycin by a random, single blind method as preventive therapy. Results were evaluable for 49 patients receiving cefamandole for a success rate of 93.9 per cent.

Cholecystitis and delayed emptying of the gallbladder.

A number of patients with symptoms of biliary colic have biliary tract disorders despite repeatedly normal oral cholecystograms. These patients will benefit from cholecystectomy. To better define such disorders, a test is needed that is noninvasive, relatively inexpensive and highly accurate.

A clinical and bacteriologic evaluation of cefamandole therapy in serious skin and skin structure infections.

The results of this study suggest that the enhanced in vitro spectrum of cefamandole may be clinically advantageous, particularly when complex mixtures of aerobic and aerobic-anaerobic bacteria are present in the lesions of serious skin and skin structure infections. The reported incidence of satisfactory clinical and bacteriologic responses appears to justify the use of cefamandole as a single agent for the treatment of these infections.