Publications by authors named "E Giuffra"
This study investigates the impact of maternal gestation diets with varying fiber contents on gene expression and chromatin accessibility in fetuses and piglets fed a low fiber diet post weaning. High-fiber maternal diets, enriched with sugar beet pulp or pea internal fiber, were compared to a low-fiber maternal diet to evaluate their effects on liver and muscle tissues. The findings demonstrate that maternal high-fiber diets significantly alter chromatin accessibility, predicted transcription factor activity and transcriptional landscape in both fetuses and piglets.
View Article and Find Full Text PDFComparative Genomics and Epigenomics of Transcriptional Regulation.
Annu Rev Anim Biosci
November 2024
Article Synopsis
- Transcriptional regulation is a complex process influenced by various physiological factors, and advancements in whole genome sequencing are enhancing our understanding of this regulation.
- Newly available comparative genomics and epigenomics data help identify important regulatory variants and noncoding elements affecting gene expression across different tissues and species.
- Future research should aim to create more diverse epigenomic data from different physiological states, with farm animals being ideal models for these studies, while also leveraging new technologies like deep learning for further insights.
Article Synopsis
- Scientists are creating better gene maps for animals, like chickens, by using new data and technology.
- The number of important genes (PCGs) and a new type called long non-coding RNAs (lncRNAs) has increased a lot in the latest chicken gene atlas.
- They used a ton of data from different chicken tissues to prove their findings and also found genes that are similar to human genes.
Article Synopsis
- The FarmGTEx project aims to create a public database of genetic variants in livestock to connect genetic differences with physical traits, benefiting both animal breeding and human health research.
- The pilot phase, PigGTEx, involved analyzing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples from pigs, leading to the development of a genotype imputation panel and associations between millions of genetic variants and transcriptomic traits across 34 different tissues.
- The study highlights the tissue-specific regulatory effects of these variants, revealing molecular mechanisms affecting 207 complex pig traits while also demonstrating the relevance of pigs as models for understanding human gene expression and genetic regulation.