Publications by authors named "E Giorgetti"
Article Synopsis
- A study was conducted to evaluate the effectiveness and safety of naporafenib, a pan-RAF kinase inhibitor, alone and in combination with spartalizumab, for patients with advanced solid tumors affected by MAPK pathway alterations.
- The phase 1 trial involved two parts: a dose-escalation to find the maximum tolerated doses and a dose-expansion focusing on patients with specific mutations (KRAS and NRAS). In total, 142 patients participated, revealing that the maximum tolerated dose of naporafenib was 600 mg twice daily.
- The results indicated that naporafenib exhibited manageable safety and potential effectiveness, with observed treatment-related adverse events and some patients experiencing partial or complete responses to the treatment.
Magneto-plasmonic nanoparticles constituted of gold and iron oxide were obtained in an aqueous environment by laser ablation of iron and gold targets in two successive steps. Gold nanoparticles are embedded in a mucilaginous matrix of iron oxide, which was identified as magnetite by both microscopic and spectroscopic analyses. The plasmonic properties of the obtained colloids, as well as their adsorption capability, were tested by surface-enhanced Raman scattering (SERS) spectroscopy using 2,2'-bipyridine as a probe molecule.
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- Age-related loss of motor neurons affects muscle function, but the exact cause is still not well understood.
- Research on mice shows that neurotoxic microglia in the spinal cord play a role in this decline, as changes in motor units occur before muscle function decreases.
- Voluntary exercise and depleting harmful microglia can prevent or reverse this decline, suggesting that targeting these microglia might help maintain muscle health in aging.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFAssessment of myelin integrity in peripheral nerve injuries and pathologies has largely been limited to post-mortem analysis owing to the difficulty in obtaining biopsies without affecting nerve function. This is further encumbered by the small size of the tissue and its location. Therefore, the development of robust, non-invasive methods is highly attractive.
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