Publications by authors named "E Gil Montalban"
Article Synopsis
- Early calorie-rich diets disrupt circadian rhythms and negatively affect memory in mice, but time-restricted feeding (TRF) can restore these issues.
- The study used methods like indirect calorimetry and behavioral tasks to analyze metabolic rhythms, memory, and molecular changes after feeding mice a high fat-high sucrose diet followed by TRF.
- Results showed that TRF improved metabolism and memory independently of body fat levels, linked to thyroid hormone signaling and gene expression changes in the hippocampus.
Article Synopsis
- Pyk2 is involved in various psychological disorders, including stress, Huntington's, and Alzheimer's, which are linked to social impairments and mitochondrial dysfunction.
- Research shows that reducing Pyk2 in mouse hippocampal neurons leads to decreased social dominance and aggression, while Pyk2 levels increase in cells from schizophrenic individuals.
- The study suggests that Pyk2 may regulate social behaviors through its impact on mitochondrial dynamics, potentially connecting Pyk2 levels to social difficulties seen in schizophrenia.
Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution to ED symptomatic dimensions remains unclear. Using chemogenetic manipulations in male mice, we found that activity of dopamine D1 receptor-expressing neurons of the NAc core subregion facilitated effort for a food reward as well as voluntary exercise, but decreased food intake, while D2-expressing neurons have opposite effects. These effects are congruent with D2-neurons being more active than D1-neurons during feeding while it is the opposite during running.
View Article and Find Full Text PDFBackground: Highly palatable food triggers behavioral responses including strong motivation. These effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (NAc). The molecular mechanisms underlying the long-lasting effects of highly palatable food on feeding behavior are poorly understood.
View Article and Find Full Text PDFArticle Synopsis
- An mpox outbreak starting in May 2022 primarily affected men who have sex with men (MSM), posing challenges in accurately determining infection times and incubation periods due to their multiple sexual encounters.
- Researchers aimed to estimate the incubation period of mpox by analyzing cases linked to specific early outbreak events in Belgium, Spain, and Germany.
- The study included data from 122 confirmed cases, revealing a median incubation period of 8 to 9 days, with 5% of cases exceeding the standard 21-day monitoring period for close contacts.