Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma.

Cancer molecular heterogeneity might explain the variable response of EGFR mutant lung adenocarcinomas to tyrosine kinase inhibitors (TKIs). We assessed the mutational status of 22 cancer genes by next-generation sequencing (NGS) in poor, intermediate or good responders to first-line gefitinib. Clinical outcome was correlated with Additional Coexisting Mutations (ACMs) and the EGFR Proportion of Mutated Alleles (PMA).

[Lipoma of the interventricular septum: its diagnosis and treatment].

We describe a case of left ventricular intramyocardial lipoma in a patient symptomatic for chest pain and syncope. The two-dimensional echocardiographic investigation showed a hyperechogenic mass inside the interventricular septum; presence of the mass was confirmed by CT scan and nuclear magnetic resonance imaging. In our experience only the CT scan was useful to clearly identify the histologic characteristics of tissue.