Publications by authors named "E Giannetta"
Dyslipidemia is a potential unfavorable prognostic factor in neuroendocrine tumors (NETs); conversely, statins proved to have antiproliferative effects in NET cell lines and could be a helpful therapeutic strategy for these patients. The main objective of this observational cohort retrospective study is to explore the associations between dyslipidemia and NET progression and evaluate the potential influence of statins in this context. 393 patients with histologically confirmed gastroenteropancreatic or bronchopulmonary NETs from six Italian centres didicated to NET diagnosis and therapy were included.
View Article and Find Full Text PDFBackground: Glucocorticoids (GC) are potent entrainers of the circadian clock. However, their effects on biological rhythms in chronic human exposure have yet to be studied. Endogenous hypercortisolism (Cushing's Syndrome, CS) is a rare condition in which circadian disruption is sustained by a tumorous source of GC excess, offering the unique opportunity to investigate GC's chronic effects in vivo.
View Article and Find Full Text PDFObjective: Fibromyalgia (FM) is a multifactorial disease characterized principally by chronic, widespread pain impairing a patient's quality of life. The management of FM requires a multidisciplinary approach that combines pharmacological and non-pharmacological strategies. Growing evidence suggests a potential beneficial role of micronutrients such as minerals and vitamins.
View Article and Find Full Text PDFArticle Synopsis
- Pseudohypoparathyroidism (PHP) is a rare hereditary disorder resulting in hormone resistance, with the study focusing on hypercalcitoninemia in affected patients.
- A retrospective analysis was conducted on 88 children and 43 adults from European endocrinology centers, revealing high rates of hypercalcitoninemia (65.9% in children, 53.5% in adults) with stable calcitonin levels over time and no correlation with parathormone levels.
- The study highlights that hypercalcitoninemia is frequently seen in PHP/iPPSD patients, particularly in specific subtypes, and suggests these patients have a distinctive response to calcium stimulation tests compared to healthy individuals and those with medullary thyroid
Article Synopsis
- The study investigates cardiac abnormalities in patients with acromegaly using cardiac magnetic resonance (CMR) to identify changes even when the condition is controlled.
- A comparison was made between 20 acromegaly patients and 17 healthy controls, revealing significant differences in various cardiac metrics such as left and right ventricular volumes and mass.
- The findings suggest that even with adequate treatment, acromegaly is associated with structural and functional heart impairments, influenced by growth hormone and sex hormones, particularly showing differences between male and female patients.