Publications by authors named "E Giani"
Introduction: This global survey evaluated the practices and adherence to international Clinical Practice Consensus Guidelines (CPCG) of physicians involved in pediatric diabetes care regarding screening, prevention and treatment of vascular complications of type 1 diabetes (T1D).
Method: A web-based survey gathering data about respondents' background, practices related to screening, prevention, and treatment of diabetic nephropathy, retinopathy, neuropathy, and macrovascular diseases and a self-assessment of physicians' knowledge based on the ISPAD CPCG 2018 were shared by ISPAD.
Results: We received 175 responses from 62 countries (60% female, median age 42.
Article Synopsis
- Glioblastoma (GBM) is a deadly brain cancer that often recurs due to the regrowth of cells that resist treatment and invade surrounding tissues.
- * Research shows that chemoradiation triggers a cell state called VC-Resist in GBM, which is more resistant to therapy and promotes tumor cell infiltration into the brain.
- * The VC-Resist state is linked to specific molecular features that enhance resistance, including DNA damage resistance and activation of pathways associated with stemness, ultimately complicating treatment efforts.
The recent pandemic prompted renewed interest in paediatric respiratory infections, including whether co-infections - particularly with RSV - have an adverse prognostic impact. We evaluated the charts of all children presenting with respiratory symptoms to our unit between October 2022 and April 2023, each of whom was subjected to a multiplex PCR assay to detect eight viral targets and one bacterial target and examine the relationships between mono- and co-infections and hospitalization outcomes. We observed that younger age and RSV infection were both associated with the need for hospitalisation and the duration of hospitalisation after adjusting for confounders.
View Article and Find Full Text PDFBackground And Aims Of The Study: Type 1 diabetes (T1D) impacts lung function and exercise capacity in adults, but limited information is available in children. We hypothesize that T1D causes alterations in pulmonary function and cardiorespiratory fitness, i.e.
View Article and Find Full Text PDFContext: Endocrine complications are common in pediatric brain tumor patients.
Objective: To describe hypothalamic-pituitary-gonadal axis (HPGA) function in patients treated in childhood for a primary brain tumor more than 5 years earlier, in order to identify risk factors for HPGA impairment.
Methods: We retrospectively included 204 patients diagnosed with a primary brain tumor before 18 years of age and monitored at the pediatric endocrinology unit of the Necker Enfants-Malades University Hospital (Paris, France) between January 2010 and December 2015.