Publications by authors named "E Geffen"
Introduction: Data regarding the incidence and outcomes of mismatch repair deficient (dMMR) rectal cancer is limited. This study characterizes dMMR rectal cancer patients, comparing response after neoadjuvant radiotherapy and oncological outcomes to mismatch repair proficient (pMMR) rectal cancer patients.
Method: A retrospective cross-sectional cohort study was conducted in 67 Dutch centers.
Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group-level processes such as subgroup formation and fission-fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing cohesion remains a gap in our knowledge of cooperative behavior in animals.
View Article and Find Full Text PDFArticle Synopsis
- Inadequate treatment of enlarged lateral lymph nodes (LLNs) in rectal cancer patients leads to higher local recurrence rates, but LLN dissection (LLND) may help reduce this risk.
- This study will evaluate the outcomes of a standardized treatment approach after multidisciplinary training, aiming for a 50% reduction in local recurrence rates among patients with rectal cancer and enlarged LLNs.
- The trial involves 200 patients and will assess important outcomes such as local recurrence rates, morbidity, disease-free survival, and quality of life over three years post-surgery, with ethical approval from a Dutch medical ethics board.
Background: High and increasing expenses on pembrolizumab ask for more cost-effective and sustainable treatment strategies to improve affordability of healthcare. Therefore, a part of the Dutch hospitals implemented an alternative, partially lower, weight-based dosing protocol for pembrolizumab. This provided the unique opportunity to compare the overall survival (OS) of the alternative pembrolizumab dosing protocol to standard dosing using a nationwide registry in non-small cell lung cancer (NSCLC) patients.
View Article and Find Full Text PDFThe standard treatment regimen for esophageal cancer is chemoradiation followed by esophagectomy. However, the use of neoadjuvant chemoradiotherapy damages the surrounding tissue, which potentially increases the risk of postoperative complications, including anastomotic leakage. The impact of definitive chemoradiotherapy (dCRT, 50.
View Article and Find Full Text PDF