Publications by authors named "E Garcia-Hernandez"
Background: Acute coronary syndrome (ACS) is the most serious manifestation of coronary heart disease. The Infarction Code (according to its initialism in Spanish, CI: Código Infarto) program aims to improve the care of these patients.
Objective: To describe the clinical presentation and outcomes of CI program in a coronary care unit (CCU).
Designing and developing inhibitors against the epigenetic target DNA methyltransferase (DNMT) is an attractive strategy in epigenetic drug discovery. DNMT1 is one of the epigenetic enzymes with significant clinical relevance. Structure-based de novo design is a drug discovery strategy that was used in combination with similarity searching to identify a novel DNMT inhibitor with a novel chemical scaffold and warrants further exploration.
View Article and Find Full Text PDFIn recent years, a worldwide reassessment of natural dyes has occurred, driven by the health and environmental issues associated with synthetic dyes. L. is a tropical tree from which wood extracts were widely used in the textile industry during the 16 century.
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- Wheat germ agglutinin (WGA) shows promise as an oral delivery agent due to its ability to bind selectively to carbohydrates and pass through biological membranes.
- The study utilized techniques like differential scanning calorimetry and molecular dynamics simulations to analyze the thermal unfolding of WGA and its domains, identifying the distinctive roles of each domain in this process.
- Findings indicate minimal interdomain cooperation but significant interaction between dimer dissociation and the unfolding of specific domains, enhancing our understanding of WGA's stability and its potential application in drug delivery.
Background: Developing effective vaccines against SARS-CoV-2 that consider manufacturing limitations, equitable access, and acceptance is necessary for developing platforms to produce antigens that can be efficiently presented for generating neutralizing antibodies and as a model for new vaccines.
Results: This work presents the development of an applicable technology through the oral administration of the SARS-CoV-2 RBD antigen fused with a peptide to improve its antigenic presentation. We focused on the development and production of the recombinant receptor binding domain (RBD) produced in E.