A pilocytic astrocytoma with novel ATG16L1::NTRK2 fusion responsive to larotrectinib: a case report with genomic and functional analysis.

The outcome of pilocytic astrocytoma (PA) depends heavily on the success of surgery. In cases where surgery alone is not curative, genetic analysis can be used to identify treatment targets for precision medicine. Here, we report a pediatric PA case that underwent incomplete surgical resection due to the tumor location.

Laser Triangulation Sensors Performance in Scanning Different Materials and Finishes.

The variety of equipment implementing laser triangulation technology for 3D scanning makes it difficult to analyse their performance, comparability, and traceability. In this study, three laser triangulation sensors arranged in different configurations are analysed using high precision spheres made of different materials and surface finishes. Three types of reference parameters were used: diameter, form error, and standard deviation of the point cloud.

Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di--Oxides Containing an Amino Acidic Side Chain.

We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity. These compounds were synthesized by combining a regioselective 2,5-piperazinedione opening and a Beirut reaction and were screened for their activity against and the promastigote and amastigote forms of representative species of the genus. Most QdNOs exhibited promising antitubercular activity with IC values ranging from 4.

Dung removal increases under higher dung beetle functional diversity regardless of grazing intensification.

Dung removal by macrofauna such as dung beetles is an important process for nutrient cycling in pasturelands. Intensification of farming practices generally reduces species and functional diversity of terrestrial invertebrates, which may negatively affect ecosystem services. Here, we investigate the effects of cattle-grazing intensification on dung removal by dung beetles in field experiments replicated in 38 pastures around the world.

Optical Characterization of Materials for Precision Reference Spheres for Use with Structured Light Sensors.

Traditionally, 3D digitizing sensors have been based on contact measurement. Given the disadvantages of this type of measurement, non-contact sensors such as structured light sensors have gained the attention of many sectors in recent years. The fact that their metrological performance is affected by the optical properties of the digitized material, together with the lack of standards, makes it necessary to develop characterization work to validate materials and calibration artifacts for the qualification and calibration of these sensors.