Publications by authors named "E Garanger"
Article Synopsis
- - This study explores the use of smart polymers, specifically amphiphilic elastin-like polypeptides (ELP--Bu), to enhance drug delivery systems by providing controlled release at targeted sites in response to chemical, physical, or biological stimuli.
- - ELP--Bu can stabilize oil-in-water emulsions, showing a droplet size of 9 ± 1 μm and maintaining stability for a month at various temperatures, while also demonstrating a trigger for drug release upon temperature increase at 42 °C.
- - These smart polymers have potential applications in treating inflammatory diseases, where increased temperature and oxidative conditions can facilitate the release of therapeutic agents.
Living cells, especially eukaryotic ones, use multicompartmentalization to regulate intra- and extracellular activities, featuring membrane-bound and membraneless organelles. These structures govern numerous biological and chemical processes spatially and temporally. Synthetic cell models, primarily utilizing lipidic and polymeric vesicles, have been developed to carry out cascade reactions within their compartments.
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- Researchers developed a biocompatible method to stabilize self-assembled nanoparticles made from amphiphilic HA-ELP block copolymers by chemically cross-linking them.
- This cross-linking involves reacting the methionine residues in the ELP block with diglycidyl ether compounds, which helps maintain the nanoparticles' structure.
- The stabilized nanoparticles show a spherical core-shell shape and retain their thermoresponsive behavior, allowing them to swell reversibly with temperature changes instead of disassembling.
Protein-polymer conjugates and polymeric nanomaterials hold great promise in many applications including biomaterials, medicine, or nanoelectronics. In this work, the first polymerization-induced self-assembly (PISA) approach performed in aqueous medium enabling protein-polymer conjugates and nanoparticles entirely composed of amino acids is presented by using ring-opening polymerization (ROP). It is indeed shown that aqueous ring-opening polymerization-induced self-assembly (ROPISA) can be used with protein or peptidic macroinitiators without prior chemical modification and afford the simple preparation of nanomaterials with protein-like property, for example, to implement biomimetic thermoresponsivity in drug delivery.
View Article and Find Full Text PDFDespite progress in bone tissue engineering, reconstruction of large bone defects remains an important clinical challenge. Here, a biomaterial designed to recruit bone cells, endothelial cells, and neuronal fibers within the same matrix is developed, enabling bone tissue regeneration. The bioactive matrix is based on modified elastin-like polypeptides (ELPs) grafted with laminin-derived adhesion peptides IKVAV and YIGSR, and the SNA15 peptide for retention of hydroxyapatite (HA) particles.
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