Publications by authors named "E Galperin"
Article Synopsis
- Shoc2 serves as a key scaffold protein in the EGFR-mediated ERK1/2 signaling pathway, crucial for transmitting signals, but its exact mechanisms are still unclear.
- Variants of Shoc2 are associated with Noonan Syndrome with Loose anagen Hair, complicating the understanding of how these genetic changes affect Shoc2 function since it lacks known enzymatic activity.
- The study finds that while Shoc2 variants fail to fully activate ERK1/2 when EGFR is the main pathway, they enhance ERK1/2 phosphorylation when the AKT pathway is also activated, indicating a complex feedback regulation in the signaling cascade.
Article Synopsis
- The Shoc2 scaffold protein is essential for transmitting signals in the EGFR-mediated ERK1/2 pathway, but how it regulates this process is not fully understood.
- Mutations in Shoc2 are linked to Noonan Syndrome with Loose anagen Hair, complicating the study of its function since Shoc2 lacks known enzymatic activity.
- This research found that while Shoc2 variants cannot fully activate ERK1/2 phosphorylation as effectively as wild-type Shoc2, they can enhance ERK1/2 phosphorylation when both AKT and ERK1/2 pathways are activated, indicating a complex regulatory role for Shoc2 in signaling.
Article Synopsis
- The ERK1/2 signaling pathway is crucial for embryonic development, with the Shoc2 protein playing a key role in modulating these signals.
- Mutations in the shoc2 gene are linked to Noonan-like syndrome with loose anagen hair (NSLH), which affects tissues derived from the neural crest.
- Research using zebrafish showed that loss of Shoc2 disrupts gene expression related to neural crest development and may cause ECM turnover abnormalities observed in NSLH patients.
Article Synopsis
- * The seventh International RASopathies Symposium focused on sharing research findings to foster new discoveries and potential therapies for RASopathies.
- * This year's meeting marked a significant advance as some research is now being used clinically, specifically through the use of Ras/MAPK inhibitors for treating patients.
The ERK1/2 (also known as MAPK3 and MAPK1, respectively) signaling pathway is critical in organismal development and tissue morphogenesis. Deregulation of this pathway leads to congenital abnormalities with severe developmental dysmorphisms. The core ERK1/2 cascade relies on scaffold proteins, such as Shoc2 to guide and fine-tune its signals.
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