Publications by authors named "E Galliera"
Article Synopsis
- The study investigates how COVID-19 affects bone turnover and remodeling, an area not thoroughly examined until now, especially focusing on elderly patients facing orthopedic surgery.
- Researchers evaluated osteoimmunological biomarkers, particularly the RANKL/OPG ratio, to assess bone resorption and fragility in COVID-19-positive patients, finding significant correlations with other inflammatory markers.
- Findings suggest that using RANKL/OPG as a biomarker can enhance the clinical understanding of COVID-19's impact on bone health, particularly important for aging patients with higher risks of bone fragility during surgery.
Osteomyelitis (OM) is a major challenge in orthopedic surgery. The diagnosis of OM is based on imaging and laboratory tests, but it still presents some limitations. Therefore, a deeper comprehension of the pathogenetic mechanisms could enhance diagnostic and treatment approaches.
View Article and Find Full Text PDFInflammation is the primary response of different disorders, and these encompass a wide range of conditions in various tissues and organs [...
View Article and Find Full Text PDFSince no definitive cure for COVID-19 is available so far, one of the challenges against the disease is understanding the clinical features and the laboratory inflammatory markers that can differentiate among different severity grades of the disease. The aim of the present study is a comprehensive and longitudinal evaluation of SCD14-ST and other new inflammatory markers, as well as cytokine storm molecules and current inflammatory parameters, in order to define a panel of biomarkers that could be useful for a better prognostic prediction of COVID-19 mortality. SCD14-ST, as well as the inflammatory markers IL-6, IL-10, SuPAR and sRAGE, were measured in plasma-EDTA of ICU COVID-19 positive patients.
View Article and Find Full Text PDFBone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being , affecting bone or bone marrow, and severely impairing bone homeostasis, resulting in osteolysis. One of the characteristic features of OM is a strong state of oxidative stress (OS) with severe consequences on the delicate balance between osteoblastogenesis and osteoclastogenesis.
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