Intact, recombinant, and spliced forms of endogenous mouse mammary tumor viruses in inbred and wild mice.

Unlabelled: Endogenous retroviruses (ERVs) are chromosomally integrated viral copies that represent relics of past infections. Analysis of the sequenced genomes of 17 mouse strains, subspecies, and identified 29 ERVs of mouse mammary tumor viruses (MMTVs), termed . The 15 laboratory mouse are each present in multiple strains reflecting their common breeding history; most predate the development of inbred strains and were likely acquired by progenitors but have no orthologs in wild mice, whereas four, including the intact , were likely endogenized more recently.

Intervention to reduce barriers to type 1 diabetes self-management: Diabetes Journey study design and participant characteristics.

Most adolescents with type 1 diabetes (T1D) encounter barriers to achieving optimal glycemia, including effective planning and monitoring their T1D and problem-solving, and following through with T1D treatment decisions. Thus, the overall aim of Diabetes Journey, a randomized controlled clinical trial, was to assess the feasibility, acceptability, and preliminary efficacy of a novel, amusement park-themed, web-based mobile health (mHealth) intervention tailored for adolescents who experienced barriers to T1D self-management. Secondary aims included examining post-intervention changes in T1D health-related quality of life, T1D self-management behaviors, and hemoglobin A1c (HbA1c).

Breeding bird sensitivity to urban habitat quality is multi-scale and strongly dependent on migratory behavior.

Human-caused conversion of natural habitat areas to developed land cover represents a major driver of habitat loss and fragmentation, leading to reorganization of biological communities. Although protected areas and urban greenspaces can preserve natural systems in fragmented landscapes, their efficacy has been stymied by the complexity and scale-dependency underlying biological communities. While migratory bird communities are easy to-study and particularly responsive to anthropogenic habitat alterations, prior studies have documented substantial variation in habitat sensitivity across species and migratory groups.

Adopting a Point-of-Care Model for Genetic Testing in Children With Developmental Delays: A Case Report.

It is the current consensus amongst the psychiatric community that children undergoing evaluation for developmental delays and/or autism spectrum disorder (ASD) should be offered genetic testing early in the diagnostic process. Identifying genetic abnormalities can provide insight into patient prognosis and may reveal other medical complications that could arise throughout a patient's life. Despite these recognized benefits, genetic testing is often delayed or not offered and therefore deprives families of valuable knowledge about their child's future health outcomes.

Transmission-reducing and -enhancing monoclonal antibodies against gamete surface protein Pvs48/45.

Gamete surface protein P48/45 has been shown to be important for male gamete fertility and a strong candidate for the development of a malaria transmission-blocking vaccine (TBV). However, TBV development for homolog Pvs48/45 has been slow because of a number of challenges: availability of conformationally suitable recombinant protein; the lack of an challenge model; and the inability to produce gametocytes in culture to test transmission-blocking activity of antibodies. To support ongoing efforts to develop Pvs48/45 as a potential vaccine candidate, we initiated efforts to develop much needed reagents to move the field forward.