Publications by authors named "E Gaiffe"
Importance: Red blood cell transfusion (RBCT) is frequently required in the early post-kidney transplant period, but long-term outcomes associated with RBCT is controversial. Therefore, it may be relevant to investigate the association between RBCT characteristics and transplant outcomes.
Objective: To study the association between RBC storage duration and transplant outcomes.
Background: Acute rejection persists as a frequent complication after kidney transplantation. Defining an at-risk immune profile would allow better preventive approaches.
Methods: We performed unsupervised hierarchical clustering analysis on pre-transplant immunological phenotype in 1113 renal transplant recipients from the ORLY-EST cohort.
Article Synopsis
- Red blood cell (RBC) transfusions are often necessary shortly after kidney transplants, but their impact on long-term outcomes is not well understood.
- A nationwide study in France examined 12,559 kidney transplant patients from 2002 to 2008, finding that 28% received transfusions within the first two weeks.
- Results indicated that receiving RBC transfusions early post-transplant significantly increased the risk of transplant failure, with a hazard ratio of 1.650, suggesting these transfusions should be carefully considered.
New Insights on End-Stage Renal Disease and Healthy Individual Gut Bacterial Translocation: Different Carbon Composition of Lipopolysaccharides and Different Impact on Monocyte Inflammatory Response.
Front Immunol
September 2021
Chronic kidney disease induces disruption of the intestinal epithelial barrier, leading to gut bacterial translocation. Here, we appreciated bacterial translocation by analyzing circulating lipopolysaccharides (LPS) using two methods, one measuring only active free LPS, and the other quantifying total LPS as well as LPS lipid A carbon chain length. This was done in end-stage renal disease (ESRD) patients and healthy volunteers (HV).
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