Publications by authors named "E Gabusi"
Article Synopsis
- Scientists are exploring how piezoelectric nanomaterials and ultrasound can help repair tissues, and they found it might work well for creating cartilage.
- In their study, they used special tiny particles mixed in a gel and applied exact ultrasound settings, which helped certain cells turn into cartilage cells even better.
- They also created a model to predict how electricity from the ultrasound affects the materials at a tiny level, and the gel they used was safe and stuck well to cartilage, showing promise for future tests.
gene encodes the alpha-1 chain of type-II procollagen. Heterozygous pathogenic variants are associated with the broad clinical spectrum of genetic diseases known as type-II collagenopathies. We aimed to characterize the NM_001844.
View Article and Find Full Text PDFArticle Synopsis
- Type-2 Familial Partial Lipodystrophy (FPLD2) leads to fat loss in the trunk and limbs while causing excess fat deposits in the neck and face, linked to mutations affecting adipose tissue function.* -
- Research indicates that the mineralocorticoid receptor (MR) is crucial in the differentiation of adipose tissue, with FPLD2 affecting the MR's location within cells, resulting in abnormal fat cell development.* -
- Treatment with the MR antagonist spironolactone has shown promise in redirecting FPLD2 preadipocyte differentiation toward a healthier 'brown' fat type, which can improve fat tissue function in affected patients.*
This systematic review is focused on the main characteristics of the hydrogels used for embedding the mesenchymal stromal cells (MSCs) in in vitro/ex vivo studies, in vivo OA models and clinical trials for favoring cartilage regeneration in osteoarthritis (OA). PubMED and Embase databases were used to select the papers that were submitted to a public reference manager Rayyan Systematic Review Screening Software. A total of 42 studies were considered eligible: 25 articles concerned in vitro studies, 2 in vitro and ex vivo ones, 5 in vitro and in vivo ones, 8 in vivo ones and 2 clinical trials.
View Article and Find Full Text PDFAutophagy is a cellular process that contributes to the maintenance of cell homeostasis through the activation of a specific path, by providing the necessary factors in stressful and physiological situations. Autophagy plays a specific role in chondrocyte differentiation; therefore, we aimed to analyze this process in adipose-derived mesenchymal stromal cells (ASCs) laden in three-dimensional (3D) hydrogel. We analyzed chondrogenic and autophagic markers using molecular biology, immunohistochemistry, and electron microscopy.
View Article and Find Full Text PDF