[Preoperative polychemotherapy in the overall treatment of locally spread breast cancer (immediate results)].

Eighty three patients with locally spread cancer of the mammary gland (stage IIIb and IIIc) were subjected to the preoperative polychemotherapy with 5-fluoruracil, methotrexate, cyclophosphane, vincristine against the background of the hormonal therapy (ovarioectomy + corticosteroids). Diminishing of the tumor bulk by 50% was noted in 53 patients. In 26 cases the effect was less pronounced, no effect was observed in 4.

[Synchronous cancer of the breasts].

Observation on 16 patients with synchronous cancer of mammary glands are reported. This group comprised patients in whom tumors developed either simultaneously or with a 6-month interval. Synchronous cancer was more frequently observed in patients in the period of active menstrual-ovarian function (an average age--40.