Fine-needle aspiration technique under endoscopic ultrasound guidance: A technical approach for RNA profiling of pancreatic neoplasms.

Background: Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) has been a longstanding challenge. The prognosis of patients with PDAC depends on the stage at diagnosis. It is necessary to identify biomarkers for the detection and differentiation of pancreatic tumors and optimize PDAC sample preparation procedures for DNA and RNA analysis.

Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal.

Background: Recently, bioactive ceramics based on hydroxyapatite (HAP) and tricalcium phosphate (TCP) have been preferred as implants in bone engineering.

Aim: To study bone regeneration under conditions of filling metaphyseal defects with the original HAP-TCP composition.

Materials And Methods: The experiment was carried out on inbred rats, the observation period was 2, 4, 8 weeks.

Diagnostic Approach to Suspected Perihilar Malignancy.

Background: Cholangiocarcinomas are relatively rare tumors most frequently arising from the epithelium of the hilar bile ducts. The diagnosis is often made in advanced (symptomatic) stages, which accounts for the infavorable prognosis with a 5-year survival of less than 10%. Identification of perihilar cholangiocarcinoma (pCCA) is often challenging because there is no single method offering sufficient diagnostic accuracy.

DIAGNOSIS AND TREATMENT OF SOLID-PSEUDOPAPILLARY NEOPLASM OF PANCREAS IN A YOUNG WOMAN.

In the article we present clinical case of rare tumors of the pancreas - solid-pseudopapillary tumor. The stages of diagnostics and clinical-instrumental and morphological features. We performed spleen preserving distal pancreatectomy as a definitive treatment.