Electrophoretic Deposition of Calcium Phosphates on Carbon-Carbon Composite Implants: Morphology, Phase/Chemical Composition and Biological Reactions.

Despite a long period of application of metal implants, carbon-carbon medical composites are also widely used for bone defect prosthesis in surgery, dentistry, and oncology. Such implants might demonstrate excellent mechanical properties, but their biocompatibility and integration efficiency into the host should be improved. As a method of enhancing, the electrophoretic deposition of fine-dispersed hydroxyapatite (HAp) on porous carbon substrates might be recommended.

[Problems and perspectives in the hygienic regulation of biotechnological strains of microorganisms].

The state-of-the-art of hygienic standardization of biotechnological strains of microorganisms is considered. The last century's investigations accumulated abundant experimental data on the estimation of the adverse effect of the strains, formulated main guidelines for evaluating the negative activity of producing strains, and proposed a schematic diagram for toxicological and hygienic investigations of new biotechnological strains. Further studies made it possible to elaborate their human hazard classification, to improve study programs, to substantiate a priority list, and to develop approaches to assessing the occupational microbiological risk.

[Comparative studies of microbial strains used in biotechnology for the elaboration of biosafety standards].

Comparative studies of different microbial strains used in biotechnology as potentially hazardous for human health agents demonstrated their ability to cause adverse effects such as toxicity, immunotropic action, sensitization, and alteration of normal intestinal microflora in rats. It was shown that certain microscopic fungi of genera Aspergillus, Penicillum, and Candida as well as some gram-negative bacteria can affect the immune system and disturb the balance of microflora in rat intestines. Actinomycetes were found to produce minimal adverse effects.

[Apolipoprotein B100 as a risk factor of acute coronary syndrome and this risk factor effect on arterial hypertension in patients with ischemic heart disease].

Aim: To clarify correlations between an elevated concentration of apolipoprotein B100 (apoB) in blood plasma and risk of acute coronary syndrome (ACS); to study apoB level in hypertensive patients and its correlation with ischemic heart disease (IHD) risk in these patients.

Material And Methods: Lipid serum spectrum (cholesterol, triglycerides (TG), lipoprotein a (Lpa) and apoB was studied in 456 patients with ACS by NYHA criteria, 119 patients with chronic IHD and 86 patients free of cardiovascular diseases (controls). All 575 patients with IHD were divided into those with and without hypertension (426 and 149 patients, respectively).