Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons.

Background/objectives: The role of α-synuclein (α-syn) pathology in Parkinson's disease (PD) is well established; however, effective therapies remain elusive. Two mechanisms central to PD neurodegeneration are the intracellular aggregation of misfolded α-syn and the uptake of α-syn aggregates into neurons. Cationic arginine-rich peptides (CARPs) are an emerging class of molecule with multiple neuroprotective mechanisms of action, including protein stabilisation.

Insights and Questions for Success in a Pharmacy Academic Career.

An individual's insights into success during an academic career are enhanced by observing successful long-term career academics and staff members within our colleges/schools of pharmacy and across the academy. What were the reasons for the success of these individuals? Based on these observations, we propose 5 simple insights that can aid in navigating organizational sub-cultures and cultures. These insights include knowing their WHY, utilizing the 24 to 48-Hour Rule to maintain resilience, demonstrating basic courtesy and politeness in interpersonal interactions, recognizing the impact of words in written communication, and optimizing the use of communication methods beyond email and text messages.

Blood Culture Use in Medical and Surgical Intensive Care Units and Wards.

Importance: Blood culture (BC) use benchmarks in US hospitals have not been defined.

Objective: To characterize BC use in adult intensive care units (ICUs) and wards in US hospitals.

Design, Setting, And Participants: A retrospective cross-sectional study of BC use in adult medical ICUs, medical-surgical ICUs, medical wards, and medical-surgical wards from acute care hospitals from the 4 US geographic regions was conducted.

Impact of Body Mass Index on Operative Time in Women Undergoing Benign Hysterectomy.

Background: Optimization of surgical scheduling represents an opportunity to improve resource utilization and increase patient access. Increasing body mass index (BMI) has been associated with increased operating time and may provide an opportunity to more accurately predict operating time.

Objective: To investigate the relationship between BMI and operative time for benign hysterectomy and develop a predictive model for hysterectomy operating time based on patient BMI.