Serum miR-181a and miR-25 in patients with malignant and benign breast diseases.

Breast tumor diseases include a wide range of pathologies that require different approaches to their treatment. MicroRNA (miR) levels, reflecting regulation of the gene expression involved in tumorigenesis, can be diagnostic and prognostic markers of breast diseases. The levels of circulating miR-181a and miR-25 were measured in patients with benign breast diseases (BBD), patients with invasive carcinoma of a nonspecific type (ICNT) and also in conditionally healthy women.

Immuno-hormonal network in postmenopausal women: disturbance in breast cancer patients.

Introduction: Antibodies to estradiol and progesterone (Es and Pg) modulated their blood serum concentration and biological effects in immunized animals. Antibodies to membrane steroid receptors acted as hormone agonists or antagonists in cell cultures.

Material And Methods: Here we studied the levels of Es and Pg, idiotypic immunoglobulin (Ig) A1 and anti-idiotypic IgG2 specific to Es and Pg in the serum of postmenopausal women (82 healthy donors and 443 breast cancer patients).

Threshold values of antibodies to estrogen, progesteron and benzo [a] pyrene as a risk factor for the development of endometriosis.

Objectives: The objective of the study was to determine the level of antibodies (AB) of Ig classes A and G to estradiol (E2), progesterone (P) and benzo [a] pyrene (Bp) in patients with endometriosis of various severity and estimate their threshold values as a risk factor for the development of endometriosis.

Methods: A retrospective case-control study was performed. The study involved 200 women.

Inversion of natural immuno-hormonal interactions under influence of antibodies against environmental chemical carcinogens.

In this article we present a hypothesis that interactions between sex hormones and specific antibodies change inversely in presence of antibodies against environmental carcinogens. Natural occurrence antibodies to estradiol (E2) and progesterone (Pg) do not influence on E2 concentration, but antibodies to Pg increase Pg concentration in blood serum of postmenopausal healthy women with low levels of antibodies against benzo[a]pyrene (Bp). Thereby natural occurrence antibodies to Pg inhibit the promotion of breast carcinogenesis.

Immunomodulation of carcinogens-induced steroids-dependent human diseases.

The experimental and clinical data about antibodies against environmental chemical carcinogens and endogenous steroids are represented. The conception of immunomodulation of carcinogens- and steroids-dependent human diseases is proposed. It is postulated that antibodies to polycyclic aromatic hydrocarbons and heterocyclic amines in cooperation with antibodies to cholesterol, sex hormones, mineralo- and glucocorticoids stimulate or inhibit cancer, malformation, cardiovascular and autoimmune diseases depending on their personal combination.