Long-Acting Injectable Prep for People Who Inject Drugs at a Syringe Services Program: A Qualitative Acceptability and Feasibility Study.

Although people who inject drugs (PWID) are at high risk of acquiring HIV, knowledge and uptake of pre-exposure prophylaxis (PrEP) for HIV prevention among this population remain low due to numerous psychosocial and structural barriers. Multiple implementation strategies have been proposed to address this gap, notably providing long-acting injectable (LAI) formulations of PrEP and offering PrEP at syringe services programs (SSPs). This qualitative study explores the acceptability and feasibility of offering LAI-PrEP for PWID at risk for HIV at Florida's first legal SSP.

Shape-responsive host-guest chemistry: metal-free tetracationic porphyrin nonplanarity promoted by clay mineral interactions assessed by theoretical simulations.

Distortions in the porphyrin core from planarity can trigger a unique structure-property relationship, imparting its basicity, chemical stability, redox potential, and excited-state energetics, among other properties. The colour change promoted by such distortion is signed by red shifts in its electronic absorption spectra. The adsorption of guest -substituted free-base porphyrin species onto inorganic hosts, such as clay minerals (layered aluminium or magnesium silicates), is known to further promote colour changes.

State and territory immunization program activities and their association with human papillomavirus vaccine initiation in the United States of America: A multilevel approach.

This study evaluates the association between immunization program (IP) activities aimed at increasing HPV vaccination among adolescents and their impact on initiation rates. Our data sources are: (i) 2016 AIM Annual Survey and (ii) 2019 National Immunization Survey-Teen. We estimated the prevalence of HPV vaccine initiation using a multilevel Poisson model, combining state-level IP data and individual characteristics of adolescents.

Impacts of acid mine drainage remediation in the largest gold mine of Latin America on natural water bodies in the Dominican Republic.

Impacts of the acid mine drainage (AMD) remediation are investigated on the largest gold mine in Latin America, located in the Dominican Republic. Geochemical analysis of suspended matter in water performed in 2022 on water bodies located downstream to the mine, namely, the Margajita River and Lake Hatillo, are compared with analyses made in 2007, before the AMD remediation. The results for the Margajita River show a strong decrease in heavy metal and metalloid concentrations in the dissolved phase for Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Sb, and Pb (between 89.