Publications by authors named "E G Morrone"
We report the design and development of a novel multifunctional nanostructure, RB-AuSiO_HSA-DOX, where tri-modal cancer treatment strategies-photothermal therapy (PTT), photodynamic therapy (PDT), chemotherapy-luminescent properties and targeting are integrated into the same scaffold. It consists of a gold core with optical and thermo-plasmonic properties and is covered by a silica shell entrapping a well-known photosensitizer and luminophore, Rose Bengal (RB). The nanoparticle surface was decorated with Human Serum Albumin (HSA) through a covalent conjugation to confer its targeting abilities and as a carrier of Doxorubicin (DOX), one of the most effective anticancer drugs in clinical chemotherapy.
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- Targeting the interactions between tumor cells and their surrounding stroma presents a new approach for cancer therapy, potentially improving treatment efficacy against tumor growth, progression, and resistance to chemotherapy.
- Researchers developed gold-core/silica-shell nanoparticles embedded with an iridium(III) complex and decorated them with aptamers that target specific receptors (EGFR and PDGFRβ) on tumor and stromal cells, respectively.
- Results demonstrated that these dual-targeted nanoparticles entered and killed cancer cells more effectively than those targeting only one receptor, especially in complex stroma-rich tumor models, indicating a promising strategy in cancer treatment.
Background: Obstructive sleep apnea affects a consistent percentage of the population, and only a minority of patients have been diagnosed and treated because of a discrepancy between resources available for diagnosis and the epidemiology of a disorder possibly affecting nearly one billion people in the world.
Aim: We conducted a study to compare a standard home respiratory monitoring system (Nox T3) with a novel device (Airgo™) consisting of an elastic band and a small recorder, light, comfortable for the patient, and low-cost complete with automatic analysis of the data that produces a screening report indicating the type and severity of sleep respiratory disorder.
Patients And Results: We examined 120 patients, reduced to 118 for technical problems.
Background: Obstructive sleep apnea (OSA) is often associated to mood disorders and anxiety symptoms that may influence negatively the treatment approach. However, the relationship between anxiety, depression and adherence to treatment is still unclear. We investigate the presence of anxiety and depressive symptoms in newly diagnosed OSA patients and the link between psychological symptoms and acceptance or adherence to CPAP after one year.
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