Publications by authors named "E G Michel"
Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 (DHX15 in humans) to productively remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a herein and previously characterized activators, Tma23 and Pxr1, respectively, defines segments that organize Prp43 function during ribosome assembly. In addition to the activating G-patch, we discover an inhibitory segment within Tma23 and Pxr1, I-patch, that restrains Prp43 ATPase activity.
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- The study investigates how the duration of ex-vivo heart perfusion (EVHP) affects patient outcomes after DCD heart transplantation, using data from 12/2019 to 09/2023.
- Results show that recipients of hearts with prolonged perfusion times (over 8.3 hours) had significantly higher 6-month mortality rates compared to those with standard perfusion times, though early 30-day mortality rates were similar.
- The findings indicate that longer EVHP durations could negatively impact long-term survival and increase hospital stay or dialysis requirement, suggesting the need for further research on improving organ preservation during EVHP.
Cortical circuits contain multiple types of inhibitory neurons which shape how information is processed within neuronal networks. Here, we asked whether somatostatin-expressing (SST) and vasoactive intestinal peptide-expressing (VIP) inhibitory neurons have distinct effects on population neuronal responses to noise bursts of varying intensities. We optogenetically stimulated SST or VIP neurons while simultaneously measuring the calcium responses of populations of hundreds of neurons in the auditory cortex of male and female awake, head-fixed mice to sounds.
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- The study investigates the potential impact of cannulation timing (daytime vs. nighttime/weekend) on patient outcomes for venoarterial extracorporeal membrane oxygenation (VA-ECMO).
- It was conducted as a retrospective cohort study at a large academic medical center, examining 468 patients who underwent VA-ECMO cannulation from 2011 to 2021.
- The findings suggest that cannulating VA-ECMO at night or on weekends does not significantly affect one-year mortality rates or the need for renal replacement therapy, indicating that such procedures can be safely performed during these times.
Background: Donation after circulatory death (DCD) and ex-vivo lung perfusion (EVLP) have been adopted to expand the donor pool in lung transplantation, but outcomes data have been conflicting. This study explores outcomes of DCD and EVLP lung transplantation in the modern era.
Methods: The United Network for Organ Sharing database was queried for adult lung transplants from January 1, 2015 to March 1, 2023.