Publications by authors named "E G M Olde Bijvank"
Article Synopsis
- Vaccine responsiveness tends to decrease in older adults, complicating efforts to create effective vaccination strategies for infectious diseases in this age group.
- In the VITAL clinical trials, participants of different age groups were given various vaccines, revealing that older adults had lower antibody responses to the primary vaccines compared to younger adults.
- The study also found that about 10% of participants, particularly older males, showed consistently low responses to multiple vaccines, highlighting the need for targeted vaccination strategies for at-risk groups.
Article Synopsis
- Streptococcus pneumoniae is a bacteria that can make kids and older people very sick.
- Scientists checked the levels of special antibodies (IgG) in different age groups to see how the body fights this bacteria.
- They found that babies have low antibody levels, which grow in adults but decrease as people get older, showing how our immune defenses change throughout life.
Effective vaccine-induced immune responses are particularly essential in older adults who face an increased risk of immunosenescence. However, the complexity and variability of the human immune system make predicting vaccine responsiveness challenging. To address this knowledge gap, our study aimed to characterize immune profiles that are predictive of vaccine responsiveness using "immunotypes" as an innovative approach.
View Article and Find Full Text PDFVaccine-induced protection against severe COVID-19, hospitalization, and death is of the utmost importance, especially in the elderly. However, limited data are available on humoral immune responses following COVID-19 vaccination in the general population across a broad age range. We performed an integrated analysis of the effect of age, sex, and prior SARS-CoV-2 infection on Spike S1-specific (S1) IgG concentrations up to three months post-BNT162b2 (Pfizer/BioNTech; Comirnaty) vaccination.
View Article and Find Full Text PDFImmunosenescence describes immune dysfunction observed in older individuals. To identify individuals at-risk for immune dysfunction, it is crucial to understand the diverse immune phenotypes and their intrinsic functional capabilities. We investigated immune cell subsets and variation in the aging population.
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